GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UVM | cis | rs2985684 | 1 | rs7142457 | chr14:50097862 | RPL36AL | chr14:50085407-50087349:- | 0.54 | 5.79 | 3.51E-7 | Carotid intima media thickness |
| UVM | cis | rs2239557 | 1 | rs7153160 | chr14:74509377 | LIN52 | chr14:74551656-74667117:+ | 0.44 | 5.65 | 5.92E-7 | Common traits (Other) |
| UVM | cis | rs2239557 | 1 | rs7153587 | chr14:74509660 | LIN52 | chr14:74551656-74667117:+ | 0.44 | 5.65 | 5.92E-7 | Common traits (Other) |
| UVM | cis | rs2239557 | 1 | rs7157566 | chr14:74649129 | LIN52 | chr14:74551656-74667117:+ | -0.44 | -5.65 | 5.92E-7 | Common traits (Other) |
| UVM | cis | rs78153629 | 1 | rs7164132 | chr15:40675155 | C15orf23 | chr15:40674922-40686488:+ | 0.93 | 6.05 | 1.34E-7 | Heschl's gyrus morphology |
| UVM | cis | rs78153629 | 1 | rs7166991 | chr15:40671957 | C15orf23 | chr15:40674922-40686488:+ | 0.89 | 6.18 | 8.36E-8 | Heschl's gyrus morphology |
| UVM | cis | rs78153629 | 1 | rs7169404 | chr15:40675443 | C15orf23 | chr15:40674922-40686488:+ | 0.9 | 5.65 | 5.93E-7 | Heschl's gyrus morphology |
| UVM | cis | rs6500602 | 1 | rs7204827 | chr16:4467533 | HMOX2 | chr16:4524719-4560347:+ | 0.46 | 4.72 | 1.68E-5 | Schizophrenia |
| UVM | cis | rs9902453 | 1 | rs7207021 | chr17:28400516 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9902453 | 1 | rs7212497 | chr17:28335949 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs8078723 | 1 | rs7214085 | chr17:38169095 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -7.55 | 4.73E-10 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| UVM | cis | rs9902453 | 1 | rs7221743 | chr17:28407876 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9902453 | 1 | rs7222308 | chr17:28277041 | EFCAB5 | chr17:28256874-28435469:+ | 0.39 | 4.9 | 8.89E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9902453 | 1 | rs7223786 | chr17:28332107 | EFCAB5 | chr17:28256874-28435469:+ | -0.4 | -5.08 | 4.7E-6 | Coffee consumption (cups per day) |
| UVM | cis | rs9876781 | 1 | rs725309 | chr3:48418708 | TREX1 | chr3:48501186-48509043:+ | 0.4 | 4.97 | 6.82E-6 | Longevity |